Mutation of the prothrombin gene and thrombotic events in patients with polycythemia vera or essential thrombocythemia: a cohort study

The association between a prothrombin mutation and the risk of thrombosis was analyzed in 214 patients with polycythemia vera or essential thrombocythemia. The rate for venous thrombotic events was 14.7/100 patient-years in patients with the prothrombin mutation compared to 0.8 in patients without t...

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Veröffentlicht in:	Haematologica (Roma) 2005-03, Vol.90 (3), p.408-410
Hauptverfasser:	Gisslinger, H, Mullner, M, Pabinger, I, Heis-Vahidi-Fard, N, Gisslinger, B, Brichta, A, Bachleitner-Hofmann, T, Mannhalter, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cohort Studies Female Humans Male Middle Aged Mutation Polycythemia Vera - complications Polycythemia Vera - epidemiology Polycythemia Vera - genetics Prothrombin - genetics Thrombocythemia, Essential - complications Thrombocythemia, Essential - epidemiology Thrombocythemia, Essential - genetics Thrombosis - etiology Thrombosis - genetics
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Zusammenfassung:	The association between a prothrombin mutation and the risk of thrombosis was analyzed in 214 patients with polycythemia vera or essential thrombocythemia. The rate for venous thrombotic events was 14.7/100 patient-years in patients with the prothrombin mutation compared to 0.8 in patients without the mutation (rate ratio 17.5).
ISSN:	0390-6078 1592-8721