Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist

Nociceptin activation of ORL1 (opioid receptor-like 1 receptor) has been shown to antagonize mu receptor-mediated analgesia at the supraspinal level. ORL1 and mu-opioid receptor (muR) are co-expressed in several subpopulations of CNS neurons involved in regulating pain transmission. The amino acid s...

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Veröffentlicht in:	Journal of neurochemistry 2005-03, Vol.92 (6), p.1285-1294
Hauptverfasser:	Wang, Hung-Li, Hsu, Chia-Yu, Huang, Pei-Chen, Kuo, Yo-Li, Li, Allen H, Yeh, Tu-Hsueh, Tso, An-Swe, Chen, Ying-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Analgesics, Opioid - pharmacology Animals Cell Line Central Nervous System - drug effects Central Nervous System - metabolism Dimerization Enkephalin, Ala-MePhe-Gly- - pharmacology Humans Mitogen-Activated Protein Kinase 1 - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Neurons - drug effects Neurons - metabolism Pain - genetics Pain - metabolism Pain - physiopathology Protein Structure, Tertiary - physiology Rats Receptors, Opioid - chemistry Receptors, Opioid - genetics Receptors, Opioid - metabolism Receptors, Opioid, mu - agonists Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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