3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.

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Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (6), p.1557-1560
Hauptverfasser: SHCHERBAKOVA, Irina, BALANDRIN, Manuel F, FOX, John, GHATAK, Anjan, HEATON, William L, CONKLIN, Rebecca L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Male
Medical sciences
Models, Chemical
Molecular Structure
Osteoporosis - drug therapy
Parathyroid Hormone - blood
Pharmacology. Drug treatments
Quinazolines - chemistry
Quinazolines - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Calcium-Sensing - antagonists & inhibitors
Structure-Activity Relationship
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Beschreibung
Zusammenfassung:Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.01.078