Charge-Conversional Polyionic Complex Micelles--Efficient Nanocarriers for Protein Delivery into Cytoplasm

Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linki...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-07, Vol.48 (29), p.5309-5312
Hauptverfasser:	Lee, Yan, Ishii, Takehiko, Cabral, Horacio, Kim, Hyun Jin, Seo, Ji-Hun, Nishiyama, Nobuhiro, Oshima, Hiroki, Osada, Kensuke, Kataoka, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Animals Aspartic Acid - chemistry Cell Line, Tumor charge conversion Citraconic Anhydrides - chemistry cytochromes Cytochromes c - administration & dosage Cytochromes c - chemistry Cytochromes c - pharmacokinetics Cytoplasm - metabolism Drug Carriers - chemistry drug delivery endosomes Heart Horses Humans Ions - chemistry Micelles Myocardium - enzymology Polyethylene Glycols - chemistry
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Beschreibung
Zusammenfassung:	Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200900064