Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata
Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at ora...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2005, Vol.28(3), pp.523-526 |
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| container_title | Biological & Pharmaceutical Bulletin |
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| creator | Lee, Eun Bang Kim, Oon Ja Kang, Sam Sik Jeong, Choonsik |
| description | Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine. |
| doi_str_mv | 10.1248/bpb.28.523 |
| format | Article |
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The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. 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These activities are comparable to those of cimetidine.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>antiulcer activity</subject><subject>Aralia</subject><subject>Aralia elata</subject><subject>Araliaceae</subject><subject>araloside A</subject><subject>Male</subject><subject>Oleanolic Acid - analogs & derivatives</subject><subject>Oleanolic Acid - isolation & purification</subject><subject>Oleanolic Acid - therapeutic use</subject><subject>Plant Bark</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - therapeutic use</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - pathology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE2LFDEQhoMo7rh68QdIQPAg9lj56nSfZBz2Q1gQZO8hna52M_Z0xiR98N-bpmdd8FJ1qKeeKl5C3jLYMi6bz92p2_Jmq7h4RjZMSF0pztRzsoGWNVXNVHNBXqV0AAANXLwkF0xpKaHhG3K7i3YMyfdId5-onehuyn4eHUa6D1PKPs84ZTrEcKT5AemPEDL9auMvGga67HpLcbTZviYvBjsmfHPul-T--up-f1vdfb_5tt_dVa5uVK5sK9q-7XhfN7Vw6LhjPQ6sb1qtFDjJhMDBdrJlBZda8a7udOGxQ9a2IC7Jh1V7iuH3jCmbo08Ox9FOGOZkai21FsAK-P4_8BDmOJXXDJOyFRJUveg-rpSLIaWIgzlFf7Txj2FglnBNCdfwxpRwC_zurJy7I_ZP6DnNAtysQJl6V3KdRj_h02GXdOfDGAwHUAaANyAMcGmg6JdSM9BSwGL6spoOKduf-O-Ujdm7ER-_EmtZth8n7sFGg5P4C3H-n6M</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Lee, Eun Bang</creator><creator>Kim, Oon Ja</creator><creator>Kang, Sam Sik</creator><creator>Jeong, Choonsik</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata</title><author>Lee, Eun Bang ; Kim, Oon Ja ; Kang, Sam Sik ; Jeong, Choonsik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-a939d9b2d6863cec2c1def1d897550c4133efab4916854752b6b79b2ebe19903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>antiulcer activity</topic><topic>Aralia</topic><topic>Aralia elata</topic><topic>Araliaceae</topic><topic>araloside A</topic><topic>Male</topic><topic>Oleanolic Acid - analogs & derivatives</topic><topic>Oleanolic Acid - isolation & purification</topic><topic>Oleanolic Acid - therapeutic use</topic><topic>Plant Bark</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - therapeutic use</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Eun Bang</creatorcontrib><creatorcontrib>Kim, Oon Ja</creatorcontrib><creatorcontrib>Kang, Sam Sik</creatorcontrib><creatorcontrib>Jeong, Choonsik</creatorcontrib><creatorcontrib>Duksung Women's University</creatorcontrib><creatorcontrib>aNatural Products Research Institute and College of Pharmacy</creatorcontrib><creatorcontrib>bCollege of Pharmacy</creatorcontrib><creatorcontrib>Seoul National University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Eun Bang</au><au>Kim, Oon Ja</au><au>Kang, Sam Sik</au><au>Jeong, Choonsik</au><aucorp>Duksung Women's University</aucorp><aucorp>aNatural Products Research Institute and College of Pharmacy</aucorp><aucorp>bCollege of Pharmacy</aucorp><aucorp>Seoul National University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>28</volume><issue>3</issue><spage>523</spage><epage>526</epage><pages>523-526</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. 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| fulltext | fulltext |
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| ispartof | Biological and Pharmaceutical Bulletin, 2005, Vol.28(3), pp.523-526 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - therapeutic use antiulcer activity Aralia Aralia elata Araliaceae araloside A Male Oleanolic Acid - analogs & derivatives Oleanolic Acid - isolation & purification Oleanolic Acid - therapeutic use Plant Bark Plant Extracts - isolation & purification Plant Extracts - therapeutic use Plant Roots Rats Rats, Sprague-Dawley Saponins - isolation & purification Saponins - therapeutic use Stomach Ulcer - drug therapy Stomach Ulcer - pathology |
| title | Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata |
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