Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata

Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at ora...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2005, Vol.28(3), pp.523-526
Hauptverfasser:	Lee, Eun Bang, Kim, Oon Ja, Kang, Sam Sik, Jeong, Choonsik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - therapeutic use antiulcer activity Aralia Aralia elata Araliaceae araloside A Male Oleanolic Acid - analogs & derivatives Oleanolic Acid - isolation & purification Oleanolic Acid - therapeutic use Plant Bark Plant Extracts - isolation & purification Plant Extracts - therapeutic use Plant Roots Rats Rats, Sprague-Dawley Saponins - isolation & purification Saponins - therapeutic use Stomach Ulcer - drug therapy Stomach Ulcer - pathology
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Beschreibung
Zusammenfassung:	Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.28.523