Lipoxygenase Inhibiting Constituents from Indigofera hetrantha

A lignan and two acylphloroglucinols have been isolated from the ethyl acetate soluble fraction of the whole plant of Indigofera hetrantha. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. Compounds 1—3 displayed promising inhibitory potential...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2005, Vol.53(3), pp.263-266
Hauptverfasser:	Aziz-ur-rehman, Malik, Abdul, Riaz, Naheed, Ahmad, Habib, Nawaz, Sarfraz Ahmad, Choudhary, Muhammad Iqbal
Format:	Artikel
Sprache:	eng
Schlagworte:	acylphloroglucinols Disaccharides - chemistry Disaccharides - isolation & purification Disaccharides - pharmacology enzyme inhibition Indigofera - chemistry Indigofera hetrantha Leguminosae lignan Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - isolation & purification Lipoxygenase Inhibitors - pharmacology Magnetic Resonance Spectroscopy Monosaccharides - chemistry Monosaccharides - isolation & purification Monosaccharides - pharmacology Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology Plants, Medicinal - chemistry Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	A lignan and two acylphloroglucinols have been isolated from the ethyl acetate soluble fraction of the whole plant of Indigofera hetrantha. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. Compounds 1—3 displayed promising inhibitory potential against enzyme lipoxygenase in concentration-dependent manner.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.53.263