A Chemoenzymatic Total Synthesis of (+)-Amabiline

A Chemoenzymatic Total Synthesis of (+)-Amabiline

The readily available and enzymatically derived cis-1,2-dihydrocatechol 3 has been converted, over 15 steps, into (+)-amabiline, the non-natural enantiomeric form of a crinine-type alkaloid.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2009-07, Vol.11 (14), p.3160-3162
Hauptverfasser: Findlay, Alison D, Banwell, Martin G
Format: Artikel
Sprache:eng
Schlagworte:
Amaryllidaceae Alkaloids - chemical synthesis
Amaryllidaceae Alkaloids - chemistry
Molecular Structure
Stereoisomerism
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Beschreibung
Zusammenfassung:The readily available and enzymatically derived cis-1,2-dihydrocatechol 3 has been converted, over 15 steps, into (+)-amabiline, the non-natural enantiomeric form of a crinine-type alkaloid.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol901230w