Evidence for a Re-Evaluation of the Neurochemical and Anatomical Bases of Chemotherapy-Induced Vomiting

New research into the reasons behind the vomiting caused by chemotherapy drugs is explored. The complex of neurotransmitters which are activated in the process are discussed, and a new hypothesis of the mechanisms involved is presented.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical reviews 2009-07, Vol.109 (7), p.3158-3199
Hauptverfasser:	Darmani, Nissar A, Ray, Andrew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Cannabinoids - metabolism Chemotherapy Dopamine - metabolism Eicosanoids - metabolism Gastrointestinal Tract - innervation Humans Hypotheses Neoplasms - drug therapy Nervous System - metabolism Nervous System - physiopathology Neurosciences Neurotransmitters Serotonin - metabolism Substance P - metabolism Vomiting Vomiting - chemically induced Vomiting - metabolism Vomiting - physiopathology
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Beschreibung
Zusammenfassung:	New research into the reasons behind the vomiting caused by chemotherapy drugs is explored. The complex of neurotransmitters which are activated in the process are discussed, and a new hypothesis of the mechanisms involved is presented.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr900117p