Malettinins B−D: New Polyketide Metabolites from an Unidentified Fungal Colonist of Hypoxylon Stromata (NRRL 29110)

Malettinins B−D (2−4), three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from nonsporulating cultures of an isolate of Mycelia sterilia MYC-155 (= NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2)...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-02, Vol.68 (2), p.212-216
Hauptverfasser:	Angawi, Rihab F, Swenson, Dale C, Gloer, James B, Wicklow, Donald. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Agonomycetes Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Bacillus subtilis - drug effects Biological and medical sciences Candida albicans - drug effects chemical structure Crystallography, X-Ray decay fungi Fundamental and applied biological sciences. Psychology Furans - chemistry Furans - isolation & purification Furans - pharmacology General aspects Hypoxylon malettinins Microbiology Molecular Structure Mycelia sterilia mycoparasites New Mexico Nuclear Magnetic Resonance, Biomolecular polyketides secondary metabolites spectral analysis Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Staphylococcus aureus - drug effects stereochemistry tropolone
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Beschreibung
Zusammenfassung:	Malettinins B−D (2−4), three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from nonsporulating cultures of an isolate of Mycelia sterilia MYC-155 (= NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2) and C (3) are partially reduced analogues of malettinin A and were identified by analysis of NMR and MS data. Malettinin D (4) is biogenetically similar, but possesses a new ring system, and the structure of 4 was established by single-crystal X-ray diffraction analysis.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049625r