Efficient Conversion of Biginelli 3,4-Dihydropyrimidin-2(1H)-one to Pyrimidines via PyBroP-Mediated Coupling

An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe dehydrogenation and a new mild PyBroP-mediated coupling with C, N, O, and S nucleophiles, which provides a readily accessible multifunctionali...

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Veröffentlicht in:	Journal of organic chemistry 2005-03, Vol.70 (5), p.1957-1960
Hauptverfasser:	Kang, Fu-An, Kodah, Jason, Guan, Qunying, Li, Xiaobing, Murray, William V
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Hydrogenation Molecular Structure Organic chemistry Preparations and properties Pyrimidines - chemical synthesis Pyrimidinones - chemical synthesis Pyrimidinones - chemistry
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Beschreibung
Zusammenfassung:	An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe dehydrogenation and a new mild PyBroP-mediated coupling with C, N, O, and S nucleophiles, which provides a readily accessible multifunctionalized pyrimidine template for diversity-oriented synthesis.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo040281j