Evaluation of vaginal misoprostol effect on pregnancy rate after intrauterine insemination

The goal of this study was to evaluate the effect ofmisoprostol on pregnancy rate after intrauterine insemination. This randomized double blind clinical trial study was performed on 66 (33 cases and 33 controls) infertile women who referred to infertility center of Imam Khomeini Hospital Sari, Iran for intrauterine insemination during 2006-2007. The two groups were matched for age, infertility causes and BMI. After intrauterine insemination, 200 mcg misoprostol was placed in posterior fornix of case group and a similar placebo tablet in control group. Chemical and clinical pregnancies and complications were recorded. Results were analyzed by means of SPSS 11 software, paired t-test and student t-test. The p-values of less than 0.05 were considered to be statistically significant. Chemical pregnancy (positive BHCG) occurred in 6 patients (18.2%) in each group. Clinical pregnancy occurred in 5 patients (15.15%) in case and 6 patients (18.2%) in controls. There were no significant statistical differences in complications between the two groups. Vaginal misoprostol after intrauterine insemination does not improve pregnancy rate.