Anterior hypothalamic β-adrenoceptors in chronic aortic-coarctated hypertensive rats: An interaction with central angiotensin II receptors

SUMMARY 1. The aim of the present study was to investigate the activity of anterior hypothalamic β‐adrenoceptors and angiotensin (Ang) II receptors on blood pressure in normotensive rats and aortic‐coarctated (ACo) animals at a chronic stage of hypertension. A possible interaction between β‐adrenoce...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2005-01, Vol.32 (1-2), p.30-34
Hauptverfasser:	Höcht, Christian, Opezzo, Javier AW, Gironacci, Mariela M, Peña, Clara, Taira, Carlos A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology angiotensin II Angiotensin II - metabolism Animals anterior hypothalamic area Anterior Hypothalamic Nucleus - metabolism aortic coarctation Aortic Coarctation - complications Aortic Coarctation - metabolism atenolol Blood Pressure - drug effects Blood Pressure - physiology Chronic Disease clenbuterol Clenbuterol - administration & dosage Clenbuterol - pharmacology Dose-Response Relationship, Drug experimental hypertension Female Heart Rate - drug effects Heart Rate - physiology Hypertension - complications Hypertension - metabolism isoproterenol Isoproterenol - administration & dosage Isoproterenol - pharmacology Microinjections Rats Rats, Wistar Receptors, Adrenergic, beta - metabolism Receptors, Angiotensin - metabolism β-adrenoceptor
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Zusammenfassung:	SUMMARY 1. The aim of the present study was to investigate the activity of anterior hypothalamic β‐adrenoceptors and angiotensin (Ang) II receptors on blood pressure in normotensive rats and aortic‐coarctated (ACo) animals at a chronic stage of hypertension. A possible interaction between β‐adrenoceptors and AngII pressor activity was also investigated. 2. Injection of isoproterenol (0.1–10 nmol) in the anterior hypothalamic area induced a dose‐dependent decrease in mean arterial pressure (MAP) in sham‐operated (SO), but not in ACo, animals. Isoproterenol (1 nmol) reduced blood pressure in SO rats (ΔMAP −10.1 ± 1.4 mmHg; n = 10) but not in ACo animals (ΔMAP −0.9 ± 1.6 mmHg; n = 10; P
ISSN:	0305-1870 1440-1681
DOI:	10.1111/j.1440-1681.2005.04150.x