Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels-Alder and...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (28), p.5159-5162
Hauptverfasser: Coquière, David, Bos, Jeffrey, Beld, Joris, Roelfes, Gerard
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
artificial metalloenzymes
asymmetric catalysis
Catalysis
Cattle
copper
Copper - chemistry
Diels–Alder reactions
Metalloproteins - chemistry
Michael addition
Molecular Sequence Data
Pancreatic Polypeptide - chemistry
Stereoisomerism
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Zusammenfassung:Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels-Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200901134