Impact of Delirium on Short-Term Mortality in Elderly Inpatients: A Prospective Cohort Study

Background Delirium is an important problem especially in older medical inpatients. Objective The authors asked whether delirium and its duration are associated with higher mortality in a 3-month follow-up period. Method In this prospective cohort study, inpatients age 65 and older were assessed every 48 hours with the Confusion Assessment Method. Results Of 542 patients enrolled, 192 (35.4%) developed delirium. After 3 months, mortality in the delirium cohort was 25.9%, and in the nondelirium cohort was 5.8%. Delirium was independently associated with mortality, and increased by 11% for every 48 hours of delirium. Conclusion Delirium and increased delirium durations are significantly associated with higher mortality.