Cytokines and schizophrenia: Microglia hypothesis of schizophrenia

The etiology of schizophrenia remains unclear, while there has been a growing amount of evidence for the neuroinflammation and immunogenetics, which are characterized by an increased serum concentration of several pro‐inflammatory cytokines. Despite the fact that microglia comprise only

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Bibliographische Detailangaben
Veröffentlicht in:	Psychiatry and clinical neurosciences 2009-06, Vol.63 (3), p.257-265
Hauptverfasser:	Monji, Akira, Kato, Takahiro, Kanba, Shigenobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Antipsychotic Agents - pharmacology antipsychotics Biological and medical sciences cytokine Cytokines - metabolism Humans inflammation Inflammation - complications Medical sciences microglia Microglia - immunology Models, Immunological Neurogenesis Neuroimmunomodulation - physiology Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Schizophrenia Schizophrenia - immunology Schizophrenia - pathology
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Beschreibung
Zusammenfassung:	The etiology of schizophrenia remains unclear, while there has been a growing amount of evidence for the neuroinflammation and immunogenetics, which are characterized by an increased serum concentration of several pro‐inflammatory cytokines. Despite the fact that microglia comprise only
ISSN:	1323-1316 1440-1819
DOI:	10.1111/j.1440-1819.2009.01945.x