Cost-effectiveness of infant vaccination with RIX4414 (Rotarix™) in the UK

Abstract This study estimated the cost-effectiveness of infant rotavirus vaccination with Rotarix™ in the UK, taking into account community rotavirus infections that do not present to the healthcare system. A Markov model compared the costs and outcomes of vaccination versus no vaccination in a hypo...

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Veröffentlicht in:	Vaccine 2009-07, Vol.27 (33), p.4520-4528
Hauptverfasser:	Martin, A, Batty, A, Roberts, J.A, Standaert, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Applied microbiology Biological and medical sciences Children & youth Cost-Benefit Analysis Cost-effectiveness Diarrhea Discount rates England - epidemiology Fundamental and applied biological sciences. Psychology Humans Immunization Infant Infants Markov Chains Microbiology Miscellaneous Models, Economic Paediatric vaccination Quality of life Quality-Adjusted Life Years Rotavirus Rotavirus Infections - economics Rotavirus Infections - epidemiology Rotavirus Infections - prevention & control Rotavirus Vaccines - economics Sensitivity analysis United Kingdom Vaccination - economics Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - economics Virology
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Zusammenfassung:	Abstract This study estimated the cost-effectiveness of infant rotavirus vaccination with Rotarix™ in the UK, taking into account community rotavirus infections that do not present to the healthcare system. A Markov model compared the costs and outcomes of vaccination versus no vaccination in a hypothetical birth cohort of children followed over a lifetime, from a societal perspective and the perspective of the National Health Service (NHS). The model estimated costs and quality-adjusted life-years (QALYs) lost due to death, hospitalisation, general practitioner (GP) consultation, emergency attendance and calls to NHS Direct for rotavirus infection in children aged
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2009.05.006