Two Flavonoid Dimers from Sarcandra hainanensis (PEI) SWAMY et BAILEY

Two new flavonoid dimers (1, 2) consisting of flavan-chalcone together with three known compounds (3—5) were isolated from the ethanol extract of the whole plants of Sarcandra hainanensis. Their structures were determined by extensive spectroscopic analysis. Human immunodeficiency virus-1 integrase...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2009/07/01, Vol.57(7), pp.743-746
Hauptverfasser:	Cao, Cong-Mei, Peng, Yong, Xu, Li-Jia, Wang, Ya-Jun, Yang, Jun-Shan, Xiao, Pei-Gen
Format:	Artikel
Sprache:	eng
Schlagworte:	Chloranthaceae Enzyme Inhibitors flavan-chalcone Flavones - chemistry flavonoid dimer HIV Integrase human immunodeficiency virus-1 integrase inhibition Magnoliopsida - chemistry Models, Molecular Molecular Structure Sarcandra hainanensis
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Beschreibung
Zusammenfassung:	Two new flavonoid dimers (1, 2) consisting of flavan-chalcone together with three known compounds (3—5) were isolated from the ethanol extract of the whole plants of Sarcandra hainanensis. Their structures were determined by extensive spectroscopic analysis. Human immunodeficiency virus-1 integrase inhibition activities of compounds 1 and 2 were evaluated and they showed weak activities with IC50 at 18.05 and 25.27 μM, respectively.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.57.743