In vitro assessment of red-cell concentrates in SAG-M filtered through the MacoPharma™ P-CAPT prion-reduction filter

This study investigated whether filtration of leucodepleted red cells in SAG‐M through the P‐CAPT™ filter in order to prevent the potential risk of vCJD infection associated with prion transmission through transfusion has any deleterious effect on red‐cell quality. Bottom‐and‐top SAG‐M leucodepleted red‐cell concentrates (24 units) were prion‐reduction filtered on the day following collection, with half of the units undergoing irradiation on day 14. A control group (12 units) was not prion filtered. Units were sampled at 7‐day intervals up to day 35 and tested using standard measures of red‐cell quality as well as prothrombin content (to examine prion filter efficacy). Haemoglobin loss per unit was ∼9 g and in some cases levels were below standard specification (40 g). Haemolysis increased significantly after filtration [0.01 (0.00‐0.05) vs. 0.23 (0.07‐0.52, p