Pathogenesis, diagnosis and treatment of Rasmussen encephalitis : A European consensus statement

Rasmussen encephalitis (RE) is a rare but severe immune-mediated brain disorder leading to unilateral hemispheric atrophy, associated progressive neurological dysfunction and intractable seizures. Recent data on the pathogenesis of the disease, its clinical and paraclinical presentation, and therape...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2005-03, Vol.128 (Pt 3), p.454-471
Hauptverfasser:	BIEN, C. G, GRANATA, T, ELGER, C. E, ANTOZZI, C, CROSS, J. H, DULAC, O, KURTHEN, M, LASSMANN, H, MANTEGAZZA, R, VILLEMURE, J.-G, SPREAFICO, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anticonvulsants - therapeutic use Autoimmunity Biological and medical sciences Cytotoxicity, Immunologic Diagnosis, Differential Encephalitis - diagnosis Encephalitis - etiology Encephalitis - immunology Encephalitis - therapy Epilepsy - etiology Human viral diseases Humans Immunomodulators Immunotherapy - methods Infectious diseases Medical sciences Neurology Pharmacology. Drug treatments T-Lymphocytes, Cytotoxic - immunology Viral diseases Viral diseases of the nervous system
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Beschreibung
Zusammenfassung:	Rasmussen encephalitis (RE) is a rare but severe immune-mediated brain disorder leading to unilateral hemispheric atrophy, associated progressive neurological dysfunction and intractable seizures. Recent data on the pathogenesis of the disease, its clinical and paraclinical presentation, and therapeutic approaches are summarized. Based on these data, we propose formal diagnostic criteria and a therapeutic pathway for the management of RE patients.
ISSN:	0006-8950 1460-2156 1460-2156
DOI:	10.1093/brain/awh415