Novel jadomycins: incorporation of non-natural and natural amino acids

[Display omitted] Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural l-amino acids, d-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (5), p.1447-1449
Hauptverfasser:	Jakeman, David L., Farrell, Spring, Young, Wendy, Doucet, René J., Timmons, Shannon C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldimine intermediates Amino Acids - chemical synthesis Amino Acids - chemistry Angucycline antibiotics Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic agents Applied microbiology Biological and medical sciences Biosynthesis Chemotherapic agents Combinatorial secondary metabolites Fundamental and applied biological sciences. Psychology General aspects Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - isolation & purification Medical sciences Microbiology Molecular Conformation Pharmacology. Drug treatments Spectrometry, Mass, Electrospray Ionization - methods Streptomyces - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	[Display omitted] Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural l-amino acids, d-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.12.082