A new C-C bond forming annulation reaction leading to pH switchable heterocycles

A new C-C bond forming annulation reaction leading to pH switchable heterocycles

A C-C bond forming reaction resulting from the alpha-addition of carbon based nucleophiles to N-bromoethyl phenanthridinium leads to the formation of 2,3-dihydro-12H-pyrrolo[1,2-f]phenanthridine-based derivatives which undergo reversible ring-opening/closing under pH control.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (27), p.4067-4069
Hauptverfasser: Kitson, Philip J, Parenty, Alexis D C, Richmond, Craig J, Long, De-Liang, Cronin, Leroy
Format: Artikel
Sprache:eng
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Zusammenfassung:A C-C bond forming reaction resulting from the alpha-addition of carbon based nucleophiles to N-bromoethyl phenanthridinium leads to the formation of 2,3-dihydro-12H-pyrrolo[1,2-f]phenanthridine-based derivatives which undergo reversible ring-opening/closing under pH control.
ISSN:1359-7345
1364-548X
DOI:10.1039/b905383b