Sustained Viral Suppression and Immune Recovery in HIV Type 1—Infected Children after 4 Years of Highly Active Antiretroviral Therapy

We report the data from a long-term study of 31 human immunodeficiency virus type 1 (HIV-1)—infected children who were treated with highly active antiretroviral therapy. A high proportion of the children had undetectable HIV-1 RNA levels. CD4+ T cell counts recovered and remained stable. Adverse eve...

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Veröffentlicht in:	Clinical infectious diseases 2005-02, Vol.40 (4), p.604-608
Hauptverfasser:	Fraaij, Pieter L. A., Verweel, Gwenda, van Rossum, Annemarie M. C., van Lochem, Ellen G., Schutten, Martin, Weemaes, Corry M. R., Hartwig, Nico G., Burger, David M., de Groot, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiretroviral Therapy, Highly Active - methods Antiviral agents Biological and medical sciences CD4 Lymphocyte Count Child Child growth Child, Preschool Children Children & youth Cohort Studies Drug therapy Female Highly active antiretroviral therapy HIV HIV 1 HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Immune system Infectious diseases Male Medical sciences Pharmacology. Drug treatments Prospective Studies RNA RNA, Viral - blood Statistical median T lymphocytes Time Factors Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Viruses
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Beschreibung
Zusammenfassung:	We report the data from a long-term study of 31 human immunodeficiency virus type 1 (HIV-1)—infected children who were treated with highly active antiretroviral therapy. A high proportion of the children had undetectable HIV-1 RNA levels. CD4+ T cell counts recovered and remained stable. Adverse events were observed frequently but were mostly mild.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/427696