Experiments in Searching Small Proteins in Unannotated Large Eukaryotic Genomes

Experiments in Searching Small Proteins in Unannotated Large Eukaryotic Genomes

There is growing interest to use mass spectrometry data to search genome sequences directly. Previous work by other authors demonstrated that this approach is able to correct and complement available genome annotations. We discuss the practical difficulty of searching large eukaryotic genomes with p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of proteome research 2005-01, Vol.4 (1), p.167-174
Hauptverfasser: Colinge, Jacques, Cusin, Isabelle, Reffas, Samia, Mahé, Eve, Niknejad, Anne, Rey, Pierre-Antoine, Mattou, Hassan, Moniatte, Marc, Bougueleret, Lydie
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Amino Acid Sequence
Databases, Protein
Exons
Female
Genomics - methods
Humans
Introns
Mass Spectrometry - methods
Peptides
Pregnancy
Proteomics - methods
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:There is growing interest to use mass spectrometry data to search genome sequences directly. Previous work by other authors demonstrated that this approach is able to correct and complement available genome annotations. We discuss the practical difficulty of searching large eukaryotic genomes with peptide ion trap tandem mass spectra of small proteins (
ISSN:1535-3893
1535-3907
DOI:10.1021/pr049811i