Self-Selection in Olefin Cross-Metathesis: The Effect of Remote Functionality

Olefin cross-metathesis (CM) is potentially an attractive method for generating dynamic combinatorial libraries (DCLs). In order for the CM reaction to be useful for DCL production, the course of the reaction and product distribution must be relatively insensitive to functionality remote from the re...

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Veröffentlicht in:	Organic letters 2005-02, Vol.7 (4), p.733-736
Hauptverfasser:	McNaughton, Brian R, Bucholtz, Kevin M, Camaaño-Moure, Ana, Miller, Benjamin L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Amides - chemical synthesis Amides - chemistry Amino Acids - chemical synthesis Amino Acids - chemistry Combinatorial Chemistry Techniques Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure
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Zusammenfassung:	Olefin cross-metathesis (CM) is potentially an attractive method for generating dynamic combinatorial libraries (DCLs). In order for the CM reaction to be useful for DCL production, the course of the reaction and product distribution must be relatively insensitive to functionality remote from the reacting centers. We report on the CM of a series of allyl- and homoallylamides that are strongly dependent on remote functionality. This includes an unusual example of a cis-selective CM.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol047361u