Protein localization studies in the age of ‘Omics’

Protein localization studies in the age of ‘Omics’

As thousands of new genes are identified in genomics efforts, the rush is on to learn something about the functional roles of the proteins encoded by those genes. Clues to protein functions, activation states and protein–protein interactions have been revealed in focused studies of protein localizat...

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Veröffentlicht in:Current opinion in chemical biology 2005-02, Vol.9 (1), p.82-87
Hauptverfasser: O’Rourke, Nancy A, Meyer, Tobias, Chandy, Grischa
Format: Artikel
Sprache:eng
Schlagworte:
Aging - genetics
Animals
Genomics - methods
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
Humans
Proteins - genetics
Proteins - metabolism
Proteins - physiology
Yeasts - genetics
Yeasts - metabolism
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Zusammenfassung:As thousands of new genes are identified in genomics efforts, the rush is on to learn something about the functional roles of the proteins encoded by those genes. Clues to protein functions, activation states and protein–protein interactions have been revealed in focused studies of protein localization. With technical breakthroughs such as GFP protein tagging and recombinase cloning systems, large-scale screens of protein localization are now being undertaken.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2004.12.002