The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors

Summary Monoclonal B‐cell lymphocytosis (MBL) is an asymptomatic monoclonal expansion of

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Veröffentlicht in:	British journal of haematology 2009-07, Vol.146 (1), p.64-75
Hauptverfasser:	Rossi, Davide, Sozzi, Elisa, Puma, Alessia, De Paoli, Lorenzo, Rasi, Silvia, Spina, Valeria, Gozzetti, Alessandro, Tassi, Maristella, Cencini, Emanuele, Raspadori, Donatella, Pinto, Valeria, Bertoni, Francesco, Gattei, Valter, Lauria, Francesco, Gaidano, Gianluca, Forconi, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged B-Lymphocytes Biological and medical sciences Biomarkers, Tumor - analysis chronic lymphocytic leukaemia Complementarity Determining Regions - genetics Disease Progression Disease-Free Survival Female FISH karyotype Flow Cytometry - methods Follow-Up Studies Gene Deletion Gene Rearrangement Genes, p53 Hematologic and hematopoietic diseases Humans immunoglobulin genes Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics In Situ Hybridization, Fluorescence - methods Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytosis - genetics Lymphocytosis - immunology Lymphocytosis - mortality Male Medical sciences Middle Aged monoclonal B‐cell lymphocytosis Multigene Family Mutation Prognosis Proportional Hazards Models Survival Rate
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Zusammenfassung:	Summary Monoclonal B‐cell lymphocytosis (MBL) is an asymptomatic monoclonal expansion of
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2009.07711.x