Chemistry and Biology of Ramoplanin: A Lipoglycodepsipeptide with Potent Antibiotic Activity

Walker et. al discuss an antibiotic that belongs to a new structural class of compounds and has not shown any cross-resistance to other antibacterial agents. This antibiotic, ramoplanin, is currently in Phase III clinical trials for the prevention of vancomycin-resistant enterococcal infections in h...

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Veröffentlicht in:	Chemical reviews 2005-02, Vol.105 (2), p.449-476
Hauptverfasser:	Walker, Suzanne, Chen, Lan, Hu, Yanan, Rew, Yosup, Shin, Dongwoo, Boger, Dale L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Outer Membrane Proteins - antagonists & inhibitors Depsipeptides - chemical synthesis Depsipeptides - chemistry Depsipeptides - pharmacology Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - enzymology Microbial Sensitivity Tests Molecular Structure N-Acetylglucosaminyltransferases - antagonists & inhibitors Structure-Activity Relationship
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Zusammenfassung:	Walker et. al discuss an antibiotic that belongs to a new structural class of compounds and has not shown any cross-resistance to other antibacterial agents. This antibiotic, ramoplanin, is currently in Phase III clinical trials for the prevention of vancomycin-resistant enterococcal infections in hospitalized patients, and it possesses some potentially important advantages over many other antibiotics.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr030106n