Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dop...

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Veröffentlicht in:	Nature neuroscience 2009-07, Vol.12 (7), p.826-828
Hauptverfasser:	Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M Flint, Burke, Robert E, Li, Chenjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Antiparkinson Agents - therapeutic use Apomorphine - therapeutic use Brain - drug effects Brain - pathology Brain - physiopathology Chromosomes, Artificial, Bacterial Disease Models, Animal Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Gene Transfer Techniques Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Levodopa - therapeutic use Mice Mice, Transgenic Movement Disorders - drug therapy Movement Disorders - genetics Mutation, Missense Neurons - pathology Neurons - physiology Nomifensine - pharmacology Parkinson Disease - genetics Parkinson Disease - pathology Parkinson Disease - physiopathology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism
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Zusammenfassung:	Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.
ISSN:	1546-1726
DOI:	10.1038/nn.2349