Effects of theaflavins on melanin biosynthesis in mouse B16 melanoma cells

In this study, we examined the effects of theaflavins, polyphenols in black tea, on α melanocyte-stimulating hormone (αMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3′-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indica...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-06, Vol.73 (6), p.1429-1431
Hauptverfasser:	Yamaoka, Y.(Aichikonan Junior College, Aich (Japan)), Ohguchi, K, Itoh, T, Nozawa, Y, Akao, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biflavonoids - pharmacology Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS black tea Catechin - pharmacology Cell Line, Tumor CELLS CELLULE CELULAS DNA Primers Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology HORMONAS HORMONE HORMONES INHIBICION INHIBITION melanin MELANINAS MELANINE MELANINS Melanins - biosynthesis melanogenesis MELANOMA Melanoma, Experimental - enzymology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology MELANOME MICE Monophenol Monooxygenase - genetics Monophenol Monooxygenase - metabolism OXIDOREDUCTASES OXIDORREDUCTASAS OXYDOREDUCTASE POLIFENOLES POLYPHENOL POLYPHENOLS RATON Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics SOURIS TEA THE theaflavins tyrosinase
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Zusammenfassung:	In this study, we examined the effects of theaflavins, polyphenols in black tea, on α melanocyte-stimulating hormone (αMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3′-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.80880