Steroid withdrawal at 3 months after kidney transplantation: a comparison of two tacrolimus‐based regimens

Summary The 6 month prospective, randomized study compared the steroid‐sparing potential of two tacrolimus‐based regimens after renal transplantation. A total of 489 patients were randomized (1:1) to receive tacrolimus/mycophenolate mofetil (MMF)/steroids (n = 243; group Tac/MMF/S) or tacrolimus/aza...

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Veröffentlicht in:	Transplant international 2005-02, Vol.18 (2), p.157-162
Hauptverfasser:	Wlodarczyk, Zbigniew, Walaszewski, Janusz, Perner, Ferenc, Vitko, Stefan, Ostrowski, Marek, Bachleda, Petr, Kokot, Franciszek, Klinger, Marian, Szenohradszky, Pal, Studenik, Pavel, Navratil, Pavel, Asztalos, Laszlo, Rutkowski, Boleslaw, Kalmar, Karoly Nagy, Hickey, David
Format:	Artikel
Sprache:	eng
Schlagworte:	acute rejection Adolescent Adult Aged azathioprine Azathioprine - administration & dosage Biological and medical sciences Creatinine - blood Female General aspects Graft Rejection - drug therapy Graft Rejection - prevention & control Humans Immunosuppressive Agents - administration & dosage kidney transplantation Kidney Transplantation - adverse effects Kidney Transplantation - pathology Kidney Transplantation - physiology Male Medical sciences Methylprednisolone - administration & dosage Middle Aged mycophenolate mofetil Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives Nephrology. Urinary tract diseases Pharmacology. Drug treatments Prednisolone - administration & dosage Prospective Studies steroid withdrawal Steroids - administration & dosage tacrolimus Tacrolimus - administration & dosage
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Zusammenfassung:	Summary The 6 month prospective, randomized study compared the steroid‐sparing potential of two tacrolimus‐based regimens after renal transplantation. A total of 489 patients were randomized (1:1) to receive tacrolimus/mycophenolate mofetil (MMF)/steroids (n = 243; group Tac/MMF/S) or tacrolimus/azathioprine/steroids (n = 246; group Tac/Aza/S). At 3 months, steroids were tapered off in 267 (54.6%) patients free from steroid‐resistant acute rejection and with serum creatinine concentrations
ISSN:	0934-0874 1432-2277
DOI:	10.1111/j.1432-2277.2004.00011.x