Allogeneic Hematopoietic Stem Cell Transplantation Recipients Have Defects of Both Switched and IgM Memory B Cells

Allogeneic hematopoietic stem cell transplant (HSCT) recipients were assessed to elucidate memory B cell defects underlying their increased susceptibility to infections, particularly by encapsulated bacteria. Circulating IgM memory B cells (CD19+ , CD27+ , IgM+ ) and switched memory B cells (CD19+ ,...

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Veröffentlicht in:Biology of blood and marrow transplantation 2009-07, Vol.15 (7), p.795-803
Hauptverfasser: D'Orsogna, Lloyd J, Wright, Matthew P, Krueger, Rom G, McKinnon, Elizabeth J, Buffery, Susan I, Witt, Campbell S, Staples, Nicole, Loh, Richard, Cannell, Paul K, Christiansen, Frank T, French, Martyn A
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Sprache:eng
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Zusammenfassung:Allogeneic hematopoietic stem cell transplant (HSCT) recipients were assessed to elucidate memory B cell defects underlying their increased susceptibility to infections, particularly by encapsulated bacteria. Circulating IgM memory B cells (CD19+ , CD27+ , IgM+ ) and switched memory B cells (CD19+ , CD27+ , IgM− ) were enumerated in allogeneic HSCT recipients (n = 37) and healthy controls (n = 35). T lymphocyte subpopulations and serum levels of immunoglobulins, including IgG subclasses, and antibodies to pneumococcal polysaccharides were also assayed. Allogeneic HSCT recipients were deficient in both switched memory and IgM memory B cells compared to healthy controls (both P < .0001), irrespective of time post-HSCT. Switched memory B cell deficiency correlated with CD4+ T cell deficiency, and both correlated with serum levels of IgG1 ( P < .0001), possibly reflecting impaired B cell isotype switching in germinal centres. “Steady-state” serum levels of antibodies to pneumococcal polysaccharides did not correlate with circulating memory B cells. Graft-versus-host disease (GVHD) was associated with lower IgM memory B cell counts and lower serum levels of IgG2, IgG4, IgA, and pneumococcal antibodies. The increased susceptibility of allogeneic HSCT patients to infection may reflect a combination of memory B cell defects, which are most common in patients with a history of GVHD.
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2008.11.024