Advances in Rickettsia Pathogenicity

One century after the first description of rickettsiae as human pathogens, the rickettsiosis remained poorly understood diseases. These microorganisms are indeed characterized by a strictly intracellular location which has, for long, prohibited their detailed study. Within the last ten years, the co...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2009-05, Vol.1166 (1), p.94-105
Hauptverfasser: Balraj, Premanand, Renesto, Patricia, Raoult, Didier
Format: Artikel
Sprache:eng
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Zusammenfassung:One century after the first description of rickettsiae as human pathogens, the rickettsiosis remained poorly understood diseases. These microorganisms are indeed characterized by a strictly intracellular location which has, for long, prohibited their detailed study. Within the last ten years, the completion of the genome sequences of several strains allowed gaining a better knowledge about the molecular mechanisms involved in rickettsia pathogenicity. Here, we summarized available data concerning the critical steps of rickettsia‐host cell interactions that should contribute to tissue injury and diseases, that is, adhesion, phagosomal escape, motility, and intracellular survival of the bacteria.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1111/j.1749-6632.2009.04517.x