Relationship between severity of renal impairment and 2-year outcomes after sirolimus-eluting stent implantation

Background The presence of chronic kidney disease (CKD) is associated with an increased risk of restenosis and major adverse cardiac events (MACEs) after coronary interventions, especially in patients on hemodialysis (HD). The aim of this study was to assess the impact of varying degrees of renal im...

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Veröffentlicht in:	The American heart journal 2009-07, Vol.158 (1), p.92-98
Hauptverfasser:	Ota, Tomoyuki, MD, Umeda, Hisashi, MD, PhD, Yokota, Shigeki, MD, Miyata, Shinjiro, MD, Takamura, Atsushi, MD, Sugino, Shigeo, MD, Hayashi, Kazutaka, MD, Ishiki, Ryoji, MD, PhD, Takeichi, Yasushi, MD, PhD, Iwase, Mitsunori, MD, PhD, FACC, Inagaki, Haruo, MD, PhD, Murohara, Toyoaki, MD, PhD, FACC
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angioplasty Angioplasty, Balloon, Coronary Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Cause of Death Clinical outcomes Comorbidity Coronary Angiography Coronary Restenosis - etiology Coronary Restenosis - mortality Disease-Free Survival Drug-Eluting Stents Equipment Failure Analysis Female Follow-Up Studies Glomerular Filtration Rate - physiology Heart attacks Humans Kaplan-Meier Estimate Kidney Failure, Chronic - complications Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - mortality Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Multivariate Analysis Myocardial Infarction - diagnosis Myocardial Infarction - mortality Myocardial Infarction - therapy Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pharmacology. Drug treatments Proportional Hazards Models Renal Dialysis Renal failure Risk Factors Sirolimus - administration & dosage Stents
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Zusammenfassung:	Background The presence of chronic kidney disease (CKD) is associated with an increased risk of restenosis and major adverse cardiac events (MACEs) after coronary interventions, especially in patients on hemodialysis (HD). The aim of this study was to assess the impact of varying degrees of renal impairment on angiographic and 2-year clinical outcomes after treatment with sirolimus-eluting stents (SESs). Methods A total of 675 lesions of 593 patients treated with SES were analyzed. Patients were classified into 3 groups: 34 patients on HD; 337 patients with estimated glomerular filtration rate ≥60 mL min−1 1.73 m−2 (non-CKD group); and 222 patients who had lower estimated glomerular filtration rate
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2009.04.013