Large-scale changes in dendritic structure during reorganization of adult somatosensory cortex

In adult rat somatosensory cortex (S1), neurons are biased and have less dendritic arbor close to the border between the forepaw and lower jaw representations. Changes in sensory experience cause changes in the functional organization of the neocortex. Therefore, we examined the morphology of neuron...

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Veröffentlicht in:	Nature neuroscience 2005-02, Vol.8 (2), p.140-142
Hauptverfasser:	Hickmott, Peter W, Steen, Patricia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Mapping brief-communication Cell Count - methods Cell Size Cerebral cortex Dendrites Dendrites - metabolism Dendrites - pathology Denervation - methods Forelimb - innervation Forelimb - physiology In Vitro Techniques Jaw - innervation Jaw - physiology Lysine - analogs & derivatives Lysine - metabolism Membrane Potentials - physiology Neurobiology Neuronal Plasticity - physiology Neurons - metabolism Neurons - pathology Neuroplasticity Neurosciences Patch-Clamp Techniques - methods Physiological aspects Rats Rats, Sprague-Dawley Somatosensory Cortex - cytology Time Factors
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Zusammenfassung:	In adult rat somatosensory cortex (S1), neurons are biased and have less dendritic arbor close to the border between the forepaw and lower jaw representations. Changes in sensory experience cause changes in the functional organization of the neocortex. Therefore, we examined the morphology of neurons in the reorganized region of S1 after forepaw denervation. We found that during reorganization dendritic arbors changed to reflect the new location of the border.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1384