Aurantosides G, H, and I: Three New Tetramic Acid Glycosides from a Papua New Guinea Theonella swinhoei

Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, r...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-01, Vol.68 (1), p.104-107
Hauptverfasser:	RATNAYAKE, Anokha S., DAVIS, Rohan A., HARPER, Mary Kay, VELTRI, Charles A., ANDJELIC, Cynthia D., BARROWS, Louis R., IRELAND, Chris M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans Lithistida Marine Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Papua New Guinea Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Pyrrolidinones - chemistry Pyrrolidinones - isolation & purification Pyrrolidinones - pharmacology Theonella swinhoei Tumor Cells, Cultured
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Zusammenfassung:	Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, respectively. Aurantosides G-I (1-3) failed to show any significant cytotoxicity against the human colon tumor cell line HCT-116.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049721s