Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation

OBJECTIVES:To compare the clinical efficacy of intravenous diltiazem, digoxin, and amiodarone for acute ventricular rate (VR) control in patients with acute symptomatic atrial fibrillation (AF) necessitating hospitalization. DESIGN:Randomized control trial. SETTING:Acute emergency medical admission...

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Veröffentlicht in:	Critical care medicine 2009-07, Vol.37 (7), p.2174-2179
Hauptverfasser:	Siu, Chung-Wah, Lau, Chu-Pak, Lee, Wai-Luen, Lam, Kwok-Fai, Tse, Hung-Fat
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amiodarone - therapeutic use Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Arrhythmia Agents - therapeutic use Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Atrial Fibrillation - physiopathology Biological and medical sciences Cohort Studies Digoxin - therapeutic use Diltiazem - therapeutic use Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Female Humans Infusions, Intravenous Intensive care medicine Length of Stay Male Medical sciences Middle Aged Tachycardia, Ventricular - etiology Tachycardia, Ventricular - prevention & control Treatment Outcome
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Zusammenfassung:	OBJECTIVES:To compare the clinical efficacy of intravenous diltiazem, digoxin, and amiodarone for acute ventricular rate (VR) control in patients with acute symptomatic atrial fibrillation (AF) necessitating hospitalization. DESIGN:Randomized control trial. SETTING:Acute emergency medical admission unit in a regional teaching hospital in Hong Kong. PATIENTS:One hundred fifty adult patients with acute AF and rapid VR (>120 bpm). INTERVENTIONS:Patients were randomly assigned in 1:1:1 ratio to receive intravenous diltiazem, digoxin, or amiodarone for VR control. MEASUREMENTS AND MAIN RESULTS:The primary end point was sustained VR control (
ISSN:	0090-3493 1530-0293
DOI:	10.1097/CCM.0b013e3181a02f56