Dialyzable Carbosilane Dendrimers as Soluble Supports for the Functionalization of Pyridine Fragments via Palladium-Catalyzed Coupling Reactions

Dialyzable Carbosilane Dendrimers as Soluble Supports for the Functionalization of Pyridine Fragments via Palladium-Catalyzed Coupling Reactions

The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. N...

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Veröffentlicht in:Organic letters 2005-02, Vol.7 (3), p.363-366
Hauptverfasser: Le Nôtre, Jérôme, Firet, Judith J., Sliedregt, Leo A. J. M., van Steen, Bart J., van Koten, Gerard, Klein Gebbink, Robertus J. M.
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Dendrimers
Dialysis
Palladium - chemistry
Pyridines - chemistry
Silanes - chemistry
Solubility
Trimethylsilyl Compounds - chemistry
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Zusammenfassung:The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. Nanofiltration (dialysis) allows facile purification of the supported molecules after each step.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0480776