Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in...

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Veröffentlicht in:	Neurology 2005-01, Vol.64 (2), p.347-349
Hauptverfasser:	ASANUMA, K, MA, Y, OKULSKI, J, DHAWAN, V, CHALY, T, CARBON, M, BRESSMAN, S. B, EIDELBERG, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Carbon Radioisotopes - pharmacokinetics Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diseases of striated muscles. Neuromuscular diseases Dopamine Antagonists - pharmacokinetics Dystonia Musculorum Deformans - genetics Female Heterozygote Humans Imaging, Three-Dimensional Male Medical sciences Middle Aged Molecular Chaperones - genetics Neurology Positron-Emission Tomography Protein Binding Raclopride - pharmacokinetics Radiopharmaceuticals - pharmacokinetics Receptors, Dopamine D2 - deficiency Receptors, Dopamine D2 - metabolism
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Zusammenfassung:	To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000149764.34953.BF