Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder

Genome‐wide scans in bipolar disorder and a meta analysis on published data have provided evidence for linkage to chromosome 13q, although the reported peaks from various studies have not converged in a narrow region. Recently, single nucleotide polymorphisms (SNPs) at the G72/G30 locus have been shown to be associated with bipolar disorder suggesting its potential role in increasing disease risk. The proposed linkage region on 13q extends over a wide span, and could provide a clue to the existence of other susceptibility variants. In the present study, SNPs in the LOC93081‐KDELC1‐BIVM, a region proximal to G72, were interrogated in two bipolar family series. KDELC1 has a predicted filamin domain and BIVM contains an immunoglobulin‐like motif. The small pedigree series yielded a nominally significant global P‐value due to under‐transmission of a rare haplotype but this finding was not supported by results from the larger series and in the case‐control study that compared 278 cases and 277 controls. © 2004 Wiley‐Liss, Inc.