Enantioselective Total Synthesis of Cylindramide

Key steps in the convergent enantioselective synthesis of the cytotoxic natural product (see structural formula) are tandem Michael addition/electrophilic trapping reactions, Sonogashira coupling, Julia–Kocienski olefination, and macrocyclization. Formation of the tetramic acid completed the synthes...

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Veröffentlicht in:	Angewandte Chemie International Edition 2005-01, Vol.44 (5), p.820-822
Hauptverfasser:	Cramer, Nicolai, Laschat, Sabine, Baro, Angelika, Schwalbe, Harald, Richter, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry macrolactams Polycyclic Aromatic Hydrocarbons - chemical synthesis Polycyclic Aromatic Hydrocarbons - chemistry Porifera - chemistry Stereoisomerism tetramic acid total syntheses
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Beschreibung
Zusammenfassung:	Key steps in the convergent enantioselective synthesis of the cytotoxic natural product (see structural formula) are tandem Michael addition/electrophilic trapping reactions, Sonogashira coupling, Julia–Kocienski olefination, and macrocyclization. Formation of the tetramic acid completed the synthesis.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200461823