Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride

An improved, automated synthesis of [18F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064±3076MBq of [18F]FDOPA were produced within 120min from EOB (n=5)...

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Veröffentlicht in:	Applied radiation and isotopes 2009-09, Vol.67 (9), p.1650-1653
Hauptverfasser:	Shen, B., Ehrlichmann, W., Uebele, M., Machulla, H.-J., Reischl, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	[18F]FDOPA [18F]fluoride Aromatic amino acids Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - chemical synthesis Fluorine Radioisotopes Nucleophilic substitution PET Radiochemistry Radiopharmaceuticals - chemical synthesis
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