Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride

Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride

An improved, automated synthesis of [18F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064±3076MBq of [18F]FDOPA were produced within 120min from EOB (n=5)...

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Veröffentlicht in:Applied radiation and isotopes 2009-09, Vol.67 (9), p.1650-1653
Hauptverfasser: Shen, B., Ehrlichmann, W., Uebele, M., Machulla, H.-J., Reischl, G.
Format: Artikel
Sprache:eng
Schlagworte:
[18F]FDOPA
[18F]fluoride
Aromatic amino acids
Dihydroxyphenylalanine - analogs & derivatives
Dihydroxyphenylalanine - chemical synthesis
Fluorine Radioisotopes
Nucleophilic substitution
PET
Radiochemistry
Radiopharmaceuticals - chemical synthesis
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Beschreibung
Zusammenfassung:An improved, automated synthesis of [18F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064±3076MBq of [18F]FDOPA were produced within 120min from EOB (n=5). Radiochemical purity and enantiomeric excess were both ⩾95%. Specific activity was ca. 50GBq/μmol at EOS. This automatically operable synthesis is well suited for the multi-patient-dose routine production of n.c.a. [18F]FDOPA.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2009.03.003