Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride
An improved, automated synthesis of [18F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064±3076MBq of [18F]FDOPA were produced within 120min from EOB (n=5)...
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| Veröffentlicht in: | Applied radiation and isotopes 2009-09, Vol.67 (9), p.1650-1653 |
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| container_issue | 9 |
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| container_title | Applied radiation and isotopes |
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| creator | Shen, B. Ehrlichmann, W. Uebele, M. Machulla, H.-J. Reischl, G. |
| description | An improved, automated synthesis of [18F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064±3076MBq of [18F]FDOPA were produced within 120min from EOB (n=5). Radiochemical purity and enantiomeric excess were both ⩾95%. Specific activity was ca. 50GBq/μmol at EOS. This automatically operable synthesis is well suited for the multi-patient-dose routine production of n.c.a. [18F]FDOPA. |
| doi_str_mv | 10.1016/j.apradiso.2009.03.003 |
| format | Article |
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[18F]FDOPA.</description><subject>[18F]FDOPA</subject><subject>[18F]fluoride</subject><subject>Aromatic amino acids</subject><subject>Dihydroxyphenylalanine - analogs & derivatives</subject><subject>Dihydroxyphenylalanine - chemical synthesis</subject><subject>Fluorine Radioisotopes</subject><subject>Nucleophilic substitution</subject><subject>PET</subject><subject>Radiochemistry</subject><subject>Radiopharmaceuticals - chemical synthesis</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVpqJ20rxD21NtuRtJGK91q3DopGJJDeipFaKVZLLNeOZLWxW_fNXboMacZmO-fYT5CbilUFKi421ZmH43zKVQMQFXAKwD-gcypbFipJMBHMgclVCmh5jNyndIWAGqp2Ccyo6rmnIt6TtrFmMPOZHRFOg55g8mnInTFUNnKVMVvKld_Vt-fnhfFwZtiGG2PYb_xvbeFiafg1KSxTdnnMfswFH993pxjXT-G6B1-Jled6RN-udQb8mv142X5WK6fHn4uF-vSciFyKWsmpOCmoR3jTDAw3BrBFQXHTd02zKl75VBYuO86Z8Q0agUyay02KCXyG_L1vHcfw-uIKeudTxb73gwYxqRFwxupajqB4gzaGFKK2Ol99DsTj5qCPtnVW_1mV5_sauB6sjsFby8XxnaH7n_sonMCvp0BnP48eIw6WY-DRecj2qxd8O_d-AfL0474</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Shen, B.</creator><creator>Ehrlichmann, W.</creator><creator>Uebele, M.</creator><creator>Machulla, H.-J.</creator><creator>Reischl, G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Automated synthesis of n.c.a. 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[18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride</atitle><jtitle>Applied radiation and isotopes</jtitle><addtitle>Appl Radiat Isot</addtitle><date>2009-09</date><risdate>2009</risdate><volume>67</volume><issue>9</issue><spage>1650</spage><epage>1653</epage><pages>1650-1653</pages><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>An improved, automated synthesis of [18F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064±3076MBq of [18F]FDOPA were produced within 120min from EOB (n=5). Radiochemical purity and enantiomeric excess were both ⩾95%. Specific activity was ca. 50GBq/μmol at EOS. This automatically operable synthesis is well suited for the multi-patient-dose routine production of n.c.a. 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| fulltext | fulltext |
| identifier | ISSN: 0969-8043 |
| ispartof | Applied radiation and isotopes, 2009-09, Vol.67 (9), p.1650-1653 |
| issn | 0969-8043 1872-9800 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | [18F]FDOPA [18F]fluoride Aromatic amino acids Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - chemical synthesis Fluorine Radioisotopes Nucleophilic substitution PET Radiochemistry Radiopharmaceuticals - chemical synthesis |
| title | Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride |
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