Size Effect on Cell Uptake in Well‐Suspended, Uniform Mesoporous Silica Nanoparticles

Size Effect on Cell Uptake in Well‐Suspended, Uniform Mesoporous Silica Nanoparticles

The size of it: Mesoporous silica nanoparticles (MSNs) of controlled size in the range 30 to 280 nm are obtained by adjusting the pH of the reaction solution. The uptake of fluorescein‐labeled MSNs (green, see image) by HeLa cells is size‐dependent, with maximum uptake at a nanoparticle size of 50 n...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2009-06, Vol.5 (12), p.1408-1413
Hauptverfasser: Lu, Fang, Wu, Si‐Han, Hung, Yann, Mou, Chung‐Yuan
Format: Artikel
Sprache:eng
Schlagworte:
cell uptake
Fluorescein-5-isothiocyanate
HeLa Cells
Humans
Hydrogen-Ion Concentration
Light
mesoporous materials
Microscopy, Confocal
Microscopy, Electron, Transmission
nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Porosity
Scattering, Radiation
silica
Silicon Dioxide - chemistry
X-Ray Diffraction
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Beschreibung
Zusammenfassung:The size of it: Mesoporous silica nanoparticles (MSNs) of controlled size in the range 30 to 280 nm are obtained by adjusting the pH of the reaction solution. The uptake of fluorescein‐labeled MSNs (green, see image) by HeLa cells is size‐dependent, with maximum uptake at a nanoparticle size of 50 nm.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200900005