Sex-related Differences in Gene Expression in Salivary Glands of BALB/c Mice

Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression betwe...

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Veröffentlicht in:Journal of dental research 2005-02, Vol.84 (2), p.160-165
Hauptverfasser: Treister, N.S., Richards, S.M., Lombardi, M.J., Rowley, P., Jensen, R.V., Sullivan, D.A.
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Sprache:eng
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Zusammenfassung:Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression between males and females. Glands were collected from male and female BALB/c mice (n = 5/sex/experiment), and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs with CodeLink microarrays, and data were evaluated by GeneSifter. Our results demonstrate that significant (P < 0.05) sex-related differences exist in the expression of numerous genes in the major salivary glands, and many of these differences were tissue-specific. These findings support our hypothesis that sex-related differences in the salivary glands are due, at least in part, to tissue-specific variations in gene expression.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910508400210