1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents

Thiourea 2 was identified as a potential HDL-elevating agent from a targeted database search. Structure–activity relationship of its analogs is described. A series of 1-hydroxyalkyl-3-phenylthiourea analogs were prepared and evaluated as HDL-and Apo A–I-elevating agents. Derivatives 5h, 7j, 7n, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-02, Vol.15 (3), p.809-812
Hauptverfasser:	Coppola, Gary M., Damon, Robert E., Eskesen, J. Bruce, France, Dennis S., Paterniti, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein A-I - blood Apolipoprotein A-I - drug effects Biological and medical sciences Cholesterol - administration & dosage Cholesterol - blood General and cellular metabolism. Vitamins Humans Lipids - blood Lipoproteins, HDL - blood Lipoproteins, HDL - drug effects Male Medical sciences Pharmacology. Drug treatments Phenylthiourea - analogs & derivatives Phenylthiourea - chemical synthesis Phenylthiourea - pharmacology Rats Structure-Activity Relationship Weight Gain - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Thiourea 2 was identified as a potential HDL-elevating agent from a targeted database search. Structure–activity relationship of its analogs is described. A series of 1-hydroxyalkyl-3-phenylthiourea analogs were prepared and evaluated as HDL-and Apo A–I-elevating agents. Derivatives 5h, 7j, 7n, and 7o were found to be as effective or superior to gemfibrozil ( 1).
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.10.094