Aminoglycoside-Hybrid Ligands Targeting the Ribosomal Decoding Site

Aminoglycoside-Hybrid Ligands Targeting the Ribosomal Decoding Site

Bacterial bridges: RNA helix 44 within the small subunit of the bacterial ribosome is the target for natural aminoglycoside antibiotics of the neomycin and hygromycin classes, which bind at neighboring sites and thereby interfere with protein synthesis. We describe synthetic aminoglycoside‐hybrid li...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2005-01, Vol.6 (1), p.58-65
Hauptverfasser: Vourloumis, Dionisios, Winters, Geoffrey C, Simonsen, Klaus B, Takahashi, Masayuki, Ayida, Benjamin K, Shandrick, Sarah, Zhao, Qiang, Han, Qing, Hermann, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
aminoglycosides
Aminoglycosides - chemistry
Aminoglycosides - pharmacology
antibiotics
Base Sequence
Binding Sites
drug design
Ligands
medicinal chemistry
Molecular Sequence Data
Mutation
Protein Biosynthesis - drug effects
Protein Structure, Secondary
RNA recognition
RNA, Ribosomal - drug effects
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Zusammenfassung:Bacterial bridges: RNA helix 44 within the small subunit of the bacterial ribosome is the target for natural aminoglycoside antibiotics of the neomycin and hygromycin classes, which bind at neighboring sites and thereby interfere with protein synthesis. We describe synthetic aminoglycoside‐hybrid ligands, such as 1, designed to inhibit translation by bridging between the neamine and hygromycin binding sites.
ISSN:1439-4227
1439-7633
1439-4227
DOI:10.1002/cbic.200400197