A case of disseminated Langerhans’ cell histiocytosis treated with thalidomide

: Tumor necrosis factor alpha (TNF‐α) seems to play a key role in the pathogenesis of Langerhans’ cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF‐α. To our knowledge this is the first case of disseminated LCH successfully treated with thalid...

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Veröffentlicht in:	European journal of haematology 2005-02, Vol.74 (2), p.172-174
Hauptverfasser:	Mauro, E., Fraulini, C., Rigolin, G. M., Galeotti, R., Spanedda, R., Castoldi, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Female Histiocytosis, Langerhans-Cell - diagnostic imaging Histiocytosis, Langerhans-Cell - drug therapy Histiocytosis, Langerhans-Cell - metabolism Histiocytosis, Langerhans-Cell - pathology Humans Immunosuppressive Agents - administration & dosage Langerhans Cells - metabolism Langerhans Cells - pathology Langerhans’ cell histiocytosis lung thalidomide Thalidomide - administration & dosage Tomography, X-Ray Computed Tumor Necrosis Factor-alpha - metabolism
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Beschreibung
Zusammenfassung:	: Tumor necrosis factor alpha (TNF‐α) seems to play a key role in the pathogenesis of Langerhans’ cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF‐α. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.
ISSN:	0902-4441 1600-0609
DOI:	10.1111/j.1600-0609.2004.00358.x