Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito

Among the lipophilic extracts of seven traditional edible mushrooms, the acetone extract of Sarcodon aspratus markedly inhibited the growth of HL60 human leukemia cells and induced apoptosis after 24 h incubation. The major active component was identified as ergosterol peroxide by NMR and ESI-MS ana...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-01, Vol.69 (1), p.212-215
Hauptverfasser:	Takei, T. (Fukushima-ken. Forestry Research Centre, Koriyama (Japan)), Yoshida, M, Ohnishi Kameyama, M, Kobori, M
Format:	Artikel
Sprache:	eng
Schlagworte:	ACETONE APHYLLOPHORALES APOPTOSIS Apoptosis - drug effects Basidiomycota - chemistry Biological and medical sciences EDIBLE FUNGI ERGOSTEROL Ergosterol - analogs & derivatives Ergosterol - chemistry Ergosterol - isolation & purification Ergosterol - pharmacology ergosterol peroxide EXTRACTS Fundamental and applied biological sciences. Psychology HL-60 Cells HL60 human leukemia cells Humans LEUKAEMIA Molecular Structure NMR SPECTROSCOPY PEROXIDES Sarcodon aspratus (Berk.) S. Ito Time Factors
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Zusammenfassung:	Among the lipophilic extracts of seven traditional edible mushrooms, the acetone extract of Sarcodon aspratus markedly inhibited the growth of HL60 human leukemia cells and induced apoptosis after 24 h incubation. The major active component was identified as ergosterol peroxide by NMR and ESI-MS analysis. Ergosterol peroxide completely inhibited growth and induced apoptosis of HL60 cells at a concentration of 25 MicroM.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.69.212